Glutamate antagonists limit tumor growth
WebMay 1, 2001 · The stimulatory effect of glutamate on tumor growth under serum deprivation suggests that glutamate itself can elicit trophic effect on tumor cells. Ca 2+ … WebSep 1, 2011 · Glutamatergic signaling has also been implicated in the biology of cancer (5, 12).For example, glutamate has been demonstrated to stimulate proliferation and migration of tumor cell lines (15, 16).Gliomas with high glutamate release show a distinct growth advantage, and the NMDA receptor antagonists MK801 and memantine slow the …
Glutamate antagonists limit tumor growth
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WebThe discovery of anticancer activity of glutamate antagonists provides new challenges for cancer biologists and the pharmaceutical industry. One crucial issue to resolve is … Webmigration of tumor cells. To study the effect of glutamate on tumor growth, various Ab tumor cell lines were exposed to NMDA and AMPA antagonists isox and glutamate, …
WebJul 29, 2015 · Glutamate antagonists, for example, inhibit cell proliferation [ 8 – 10] and induce cell cycle arrest [ 11] and cell death [ 12] in some tumor entities. MK 801 was used for this purpose in many preclinical studies [ 13 ], but the psychotropic effects of this glutamate antagonist significantly restrict its clinical application. WebOct 15, 2002 · Glutamate antagonists produce morphological alterations in tumor cells, which consist of reduced membrane ruffling and pseudopodial protrusions, and decrease …
WebOct 15, 2002 · The antiproliferative effect of glutamate antagonists is Ca(2+)-dependent and results from decreased cell division and increased cell death. Glutamate … WebJun 1, 2007 · Several groups reported that glutamate receptor antagonists limit tumor growth (Arcella et al. 2005; Nicoletti et al. 2007; Rzeski et al. 2001). Recent data show that blocking expression of ...
WebNov 1, 2002 · Glutamate antagonists produce morphological alterations in tumor cells, which consist of reduced membrane ruffling and pseudopodial protrusions, and decrease their motility and invasive...
WebOct 15, 2002 · Glutamate antagonists and tumor growth. In a series of recently conducted experiments [22], we were able to demonstrate that glutamate antagonists … boclair house christmasWebSep 1, 2001 · It follows that if glutamate release by tumors is directly responsible for their growth, then blocking 'downstream' glutamate receptors should slow growth. … boc lake view branch contact numberWebSep 1, 2001 · Glutamate neurotoxicity has been implicated in stroke, head trauma, multiple sclerosis and neurodegenerative diseases. New research suggests that this abundant amino acid might also be involved... clock spring 56007621WebAntagonists of the NMDA receptor act either by competitive antagonism at the glutamate-binding site or by noncompetitive antagonism at the glycine, phencyclidine (PCP)-, and … boclair paintingWebIt will be important to decipher the molecular pathways that glutamate antagonists utilize to limit tumor growth, invasiveness, and migration. The electrophysiological and binding properties of glutamate receptor/ion channels present on tumor cells will need to be investigated as well as their subunits better characterized and sequenced. clock spring 2013 elantraWebAug 14, 2012 · Overstimulation of glutamate receptors causes increased intracellular levels of Ca 2+, which leads to apoptosis and gives glioma cells room to grow and spread ( 16 ). The limitations for growth that gliomas face because of the nonexpandable nature of the cranium necessitate damage to and elimination of normal brain tissue. boclair weddingWebMay 22, 2001 · Glutamate antagonists limit tumor growth Proc Natl Acad Sci U S A. 2001 May 22;98(11):6372-7. doi: 10.1073/pnas.091113598. Epub 2001 May 1. Authors … boc lake view branch code